## Welcome to the SIB (SimpleIsBeautiful) BLAST server

**SimpleIsBeautiful** is a novel methodology that aims to improve the
statistical assessment of hits returned from a PSI-BLAST
search to yield better delineation of true and false positives. This approach is based on the hypothesis that '*benchmarking'* hits from later iterations against hits
from iteration two where the model is least corrupted should improve
the accuracy of a PSI-BLAST search. Hence, a new figure termed Figure Of Merit (FOM) is calculated by combining *E*-values of iteration 2 with *E*-values of the final iteration. This FOM is then used to re-rank-order hits in the final iteration.

The script for the SimpleIsBeautiful algorithm is available for download here.

To learn how to use SIB-BLAST, please read the SIB-BLAST Manual.

If you would like to know more about the SimpleIsBeautiful algorithm, please refer to the following article:

M.M. Lee, M. Chan, and R. Bundschuh, *"Simple is beautiful: a straightforward approach to improve the delineation of true and false positives in PSI-BLAST searches"*,* Bioinformatics * **24** (2008) 1339-1343.