Poster abstracts

Poster number 67 submitted by David Taffany

An Ets2-Specific Transcriptional Program in Tumor-Associated Macrophages Promotes Tumor Metastasis

David A. Taffany (Department of Molecular and Cellular Biochemistry, The Ohio State University), Tahera Zabuawala (Department of Molecular and Cellular Biochemistry, Department of Molecular Genetics, The Ohio State University), Sudarshana M. Sharma (Department of Molecular and Cellular Biochemistry, The Ohio State University), Anand Merchant (Department of Molecular and Cellular Biochemistry, The Ohio State University), Kun Huang (Department of Biomedical Informatics, The Ohio State University), Gustavo Leone (Department of Molecular Genetics; Department of Molecular Virology, Immunology, and Medical Genetics; The Ohio State University)

Abstract:
This project aims to analyze the effects of Ets2 deletion specifically in the tumor-associated macrophages (TAMs) in the primary breast and metastatic lung tumor microenvironments. To this end, Ets2 was specifically deleted in the macrophage compartment using a conditional Ets2 \

Keywords: metastasis, macrophage, tumor microenvironment