Poster abstracts

Poster number 49 submitted by Yudhistira Tesla

Developing Potent Therapeutics for Liver Cancer Chemoresistance via an RNA Nanotech and Series-Circuit-Christmas-Bulb Mechanism Targeting ABC Transporters

Yudhistira Tesla (Division of Pharmaceutics and Pharmacology, College of Pharmacy; Center for RNA Nanotechnology and Nanomedicine; James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Colu), Peixuan Guo (Division of Pharmaceutics and Pharmacology, College of Pharmacy; Center for RNA Nanotechnology and Nanomedicine; James Comprehensive Cancer Center, College of Medicine, The Ohio State University, Colu)

Abstract:
Liver cancer, particularly hepatocellular carcinoma (HCC), poses significant treatment challenges due to chemoresistance and cancer recurrence. The liver's detoxification nature and ABC (ATP-Binding Cassette).Based on the understanding of the dsDNA translocating mechanism and the complete inhibition trial in the multi-homosubunit-revolving ATPase exemplified by the dsDNA packing motors by Phi29, we introduce an unprecedented approach to develop a potent HCC drug, mimicking the Series-Circuits of Christmas-Bulb, for which one bulb will silence the entire bulb chain, thus completely shut down the replication of the virus. The programmable and multivalent nature of RNA nanotechnology enables the co-delivery of multiple high-payload therapeutics to identical cancer cells by co-conjugation of the liver hepatocyte ligand resulting in a synergetic effect

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Keywords: RNA Nanotechnology, Series-Circuit Christmas Bulb Mechanisms, HCC