Poster abstracts
Poster number 4 submitted by Kyle Crocker
A quantitative model of temperature actuated DNA origami nanocaliper constructs
Kyle Crocker (Department of Physics), Joshua Johnson (Interdisciplinary Biophysics Graduate Program), Carlos Castro (Department of Mechanical and Aerospace Engineering), Ralf Bundschuh (Department of Physics)
Abstract:
Manipulating the temperature of an incorporated gold nanoparticle can be used to actuate DNA origami nanocalipers. We develop a physical model of this system that uses partition function analysis to predict the probability that the nanocaliper is open at a given temperature. The model agrees well with experimental data and the comparison between model and experimental data reveals surprising insights into the nanocaliper-nanoparticle system. Additionally, the model predicts experimental conditions that allow the actuation temperature of the nanocaliper to be tuned over a wide range of temperatures from 20oC to 60oC.
Keywords: DNA origami, Actuation, Quantitative modeling