Poster abstracts

Poster number 79 submitted by Benjamin Sunkel

Convergent CREB1/FoxA1 Transcriptional Activity Defines Castration-Resistant Prostate Cancer Gene Expression Profile

Benjamin Sunkel (Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine), Dayong Wu (Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine), Xiangtao Liu (Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine), Zhenqing Ye (Departments of Molecular Medicine and Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio ), Victor Jin (Departments of Molecular Medicine and Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio ), Qianben Wang (Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine)

Abstract:
To identify novel and perhaps targetable mechanisms of oncogenic expression contributing to androgen-dependent and castration-resistant prostate cancer (ADPC and CRPC, respectively), we have extended previous findings from Zhang, et al., Cancer Research 2011 to comprehensively identify gene expression profiles determined by the collaborative activities of the transcription factors (TFs) FoxA1 and CREB1 in the LNCaP (ADPC model) and LNCaP-abl (CRPC model, and LNCaP derivative) cell lines. By applying an integrated genomics approach, we have identified relevant pathways downstream of this co-regulatory pathway, as well as CREB1/FoxA1 target genes whose expression patterns correlate with clinical outcomes. That this pathway appears to be sensitive to compounds inhibiting CREB1 transactivation suggests a therapeutic potential in targeting cooperative TF activity in cases of advanced prostate cancer.

Keywords: Prostate Cancer, FoxA1 , CREB1