Poster abstracts

Poster number 71 submitted by Hosung Sim

Brevican, a pro-invasive matrix protein, activates PDGFR signaling and stimulates oligodendrocyte precursor recruitment in the glioma microenvironment.

Hosung Sim (Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery), Paula Agudelo (Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery), Bin Hu (Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery), Mariano S. Viapiano (Dardinger Center for Neuro-Oncology and Neurosciences, Department of Neurological Surgery)

Abstract:
Malignant gliomas are highly recurrent and virtually impossible to treat with conventional therapies. Glioma invasion, one of the major factors that promotes recurrence, may be regulated in part by interactions between glioma cells and normal neural cells that may facilitate tumor dispersion. Brevican is a brain-specific matrix protein secreted by glioma cells and cleaved by ADAMTS metalloproteases in the matrix around the tumor. This cleavage releases a 50-kDa brevican fragment (

Keywords: Brevican, Glioma, PDGFR