Poster abstracts
Poster number 44 submitted by Rebekah Strong
Bifacial peptide nucleic acid directed chemistry through U-rich internal loops
Rebekah E. Strong (The Ohio State University)
Abstract:
Deciphering RNA-protein and RNA-RNA interactions is crucial for regulating the function of the RNA. Herein, we describe a novel method to redirect native degradation using bifacial peptide nucleic acids (bPNAs). Our group has previously demonstrated a method that takes advantage of the affinity of bPNA for U-rich internal loops (URILs) in structured RNA to form triplex hybrids. These URILs can be installed in RNAs of interest and bPNA can direct the chemistry of the RNA complex. Prior work has demonstrated bPNA ability to direct chemistry following hybridization. We describe experiments herein that expand the scope of bPNA-hybrid directed chemistry.
Keywords: bPNA, U-rich internal loop, directed chemistry