Poster abstracts
Poster number 30 submitted by Kristen Navarro
Examining the functions of TMED protein family members in Caenorhabditis elegans (C. elegans)
Kristen Navarro (The Ohio State University, Department of Molecular Genetics), Helen Chamberlin (The Ohio State University, Department of Molecular Genetics)
Abstract:
The transmembrane emp24 domain (TMED) family consists of type I single-pass transmembrane proteins that are highly conserved and involved in protein secretion(Carney & Bowen, 2004; Jerome-Majewska et al., 2010; Hou et al., 2017; Hou & Jerome-Majewska, 2018).TMED proteins areinvolved in cargo protein sorting, vesicle biogenesis, and protein folding quality control (Schimmoller et al.,1995;Stamnes et al,. 1995; Lavoie et al., 1999; Wen and Greenwald, 1999).TMED family members are classified into four subfamilies based on sequence similarity: α, β, γ and δ.(Blum et al., 1996; Strating et al., 2009; Schuiki & Volchuk, 2012).TMED proteins belonging to separate subfamilies are thought to physically interact with each other to form tetramers and function properly (Hirata et al., 2013). While the function of TMED proteins has been systematically studied in yeast, their roles in multicellular animals are less well understood. Thus,we chose to examine C. elegans TMED genes to better understand the roles for this protein class in animal development.
References:
Blum R., Feick P., Puype M., Vandekerckhove J., Klengel R., Nastainczyk W. and Schulz I. (1996). Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. Journal of Biological Chemistry 271(29), 17183–17189.•
Keywords: developmental genetics , C elegans, TMED proteins